Summary on some antiviral researches
1. Niclosamide: Mode of Action: Neutralization of endosomal pH *Also affects maturation of Dengue virus (DENV) particles rendering them non-infectious (1). *It is an antiparasitic drug approved drug for human use. 2. 1-methylpropyl-2-imidazolyl disulfide (PX-12): Mode of Action: Reversible inhibition of the thioredoxin system (Trx1 system) causing a slow irreversible thioalkylation of Trx1 (2) . *Anti-HIV-1 effect. In hibited the enzymatic activity of Trx1 and the Trx1-dependent disulfide reduction of gp120. *Developed as an antitumor agent. 3. Nitazoxanide (NTZ): Mode of Action: Inhibits host ERp57 activity, causing newly synthesized F-protein misfolding, F-aggregate formation and halting F-trafficking to the host plasma membrane as reported in a prototype paramyxovirus Sendai (SeV) (3). ...