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The genetic code is a set of rules that determines how the information stored in DNA is translated into the amino acid sequence of proteins. It is essentially a mapping between nucleotide triplets, called codons, and the corresponding amino acids or other functional signals. The genetic code is universal, meaning that the same codons encode the same amino acids across all living organisms.
Key Properties of the Genetic Code
Here are some key properties of the genetic code:
Triplet Nature: The genetic code is triplet, meaning that each codon consists of three nucleotides. There are 64 possible codons (4 nucleotides raised to the power of 3), and these codons encode the 20 standard amino acids, along with start and stop signals.
Degeneracy: Degeneracy refers to the redundancy in the genetic code, where multiple codons can code for the same amino acid. Most amino acids are encoded by more than one codon, with the exception of methionine and tryptophan, which each have a single codon.
Start and Stop Codons: The genetic code includes specific codons that serve as start and stop signals for protein synthesis. The start codon, AUG (encoding methionine), initiates translation, and stop codons (UAA, UAG, UGA) signal the termination of translation.
Universal: The genetic code is nearly universal, meaning that the same codons specify the same amino acids in all known organisms, from bacteria to humans.
Non-Overlapping and Commaless: The genetic code is non-overlapping and commaless, ensuring the reading frame is maintained during translation.
Degeneracy of the Genetic Code
Degeneracy refers to the redundancy in the genetic code, where most amino acids are encoded by more than one codon. This allows for some tolerance to mutations in the DNA sequence, as certain changes may not affect the amino acid sequence of the resulting protein.
Start and Stop Codons
The genetic code includes specific codons that serve as start and stop signals for protein synthesis.
Start Codon: AUG (encodes Methionine, Met) is the start codon that initiates translation.
Stop Codons: UAA, UAG, and UGA are the stop codons that signal the termination of translation.
Universal Nature of the Genetic Code
The genetic code is nearly universal, meaning that the same codons specify the same amino acids in all known organisms, from bacteria to humans. This reflects the common ancestry of all life on Earth and provides a basis for molecular biology and evolutionary studies.
Wobble Base Pairing
The third position of the codon (the "wobble" position) exhibits more flexibility in base pairing, allowing for non-standard base pairing between the codon and anticodon during translation. This flexibility contributes to the degeneracy of the genetic code and allows for efficient and accurate translation despite minor variations in the nucleotide sequence.
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